Dental implants provide a predictable treatment option for partial and complete edentulism\nvia the placement of a fixed permanent artificial root to support prosthetic dental crowns. Despite the\nhigh survival rates, long-term dental implant failures are still reported, leading to implant removals\nand additional financial and health burdens. While extrinsic factors that improve the success\nrate of implants have been well explored, the impact of genetic factors on this matter is poorly\nunderstood. A systematic review and meta-analysis study was conducted to determine whether\ngenetic factors contribute to an increased risk of dental implant failures. A comprehensive search\nfor peer-reviewed articles on dental implants and genetic factors was performed using various\nliterature database libraries. The study design was conducted according to Preferred Reporting Items\nfor Systematic Reviews and Meta-Analysis (PRISMA) guidelines, and the obtained records were\nregistered in the International Prospective Register of Systematic Reviews (PROSPERO) database.\nAccording to the exclusion/inclusion criteria, 13 studies were eligible for this study out of 809 articles.\nThe meta-analysis of the combined association studies of DNA variations and dental implants did\nnot indicate an increased risk for implant failure due to DNA variations in IL-1B, IL-10 and TNF ... This study emphasizes the need for larger randomized controlled clinical trials to inform clinicians\nand patients about the role of genetic factors on dental implant survival and the success rate in\nhealthy and compromised patients.
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